Pros:
- great ergonomic design
- keyboard’s keypad is warped subtly to accommodate a more natural hand position
- mouse is very very very smooth and has incredibly precise (smooth) wheel scrolling
- extra programmable mouse buttons make browsing / using certain common programs much easier and more efficient.
- extra button on the keyboard for zooming works great in image editing programs
- high quality materials used for construction / mouse feels solid (not cheap)

Cons:
- Keyboard skips letters when typing sometimes if the signal is week. This is getting progressively more and more annoying. (Update: I have recently found this to happen quite often even with a fresh set of batteries and unfortunately I cannot return the keyboard because I bought it April 26th - almost 2 months ago. I might try anyways.)
- Mouse clicks aren’t recognized sometimes. I imagine this is due to a weak wireless signal, but my mouse is ony 1 1/2′ away from the antenna. Also getting progressively annoying. (Update: Still very annoying. In my opinion, this is an unnecessary cause of a progressive build up of frustration during work which causes me to be inefficient and discourteous to my co-workers.)
- ‘lock’ keys don’t have led’s (on the keyboard) like EVERY other keybord. When you hit Caps Lock, an OSD pops up saying your Caps Lock is either on or off. There are led’s on the bluetooth antenna which indicate which lock keys are on, but mine is behind my monitor so I can’t even see it.
- program specific settings for mouse do not work well when two programs with different custom settings for each program are open at the same time (ex: when photoshop and firefox are opened, the mouse reacts based on photoshop’s preferences so middle clicking a tab to close it actually switches the mouse to ultra precise mode)

Summary:
I think Microsoft missed the target a little on this product. They seemed to have the right idea at heart but just didn’t work out all the bugs before letting it go. Unfortunately I love the ergonomic design of this set plus the wireless aspect is great but the specific technical problems are sincerely annoying. It’s been suggested to me to switch to Logitec not only for their price/quality but a friend of mine told me they sent him a brand new keyboard/mouse combo after his broke… 4 years later. I think I’m heading back to the store for one of those.

So this concludes my two month review of the Microsoft Wireless Desktop 6000. Also - just to clarify, I used the product in a graphic design environment for the entire 2 month period extensively for ~8 hours a day.

Just a quick update, this thing makes me want to smash my head into a wall. Clicking the mouse buttons only works about 1 out of 5 times - every time. I’m going to try to return this thing this weekend.

Update: I’m lazy and haven’t tried to return this yet.

I give this product a thumbs down.